Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lhx3  LIM homeobox protein 3   (Synonyms: Lim3, mLim-3, P-LIM)
Results	Reference
1	J:222718 Adams KL, Rousso DL, Umbach JA, Novitch BG, Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015;6:6778
1*	J:104158 Alanentalo T, Chatonnet F, Karlen M, Sulniute R, Ericson J, Andersson E, Ahlgren U, Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns. 2006 Jan;6(2):162-70
1	J:227113 Amin ND, Bai G, Klug JR, Bonanomi D, Pankratz MT, Gifford WD, Hinckley CA, Sternfeld MJ, Driscoll SP, Dominguez B, Lee KF, Jin X, Pfaff SL, Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure. Science. 2015 Dec 18;350(6267):1525-9
1	J:57340 Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S, Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron. 1999 Aug;23(4):659-74
1	J:257081 Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL, Presenilin-dependent receptor processing is required for axon guidance. Cell. 2011 Jan 7;144(1):106-18
1*	J:290740 Brachet C, Kozhemyakina EA, Boros E, Heinrichs C, Balikova I, Soblet J, Smits G, Vilain C, Mathers PH, Truncating RAX Mutations: Anophthalmia, Hypopituitarism, Diabetes Insipidus, and Cleft Palate in Mice and Men. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2925-2930
1	J:309359 Brinkmeier ML, Bando H, Camarano AC, Fujio S, Yoshimoto K, de Souza FS, Camper SA, Rathke's cleft-like cysts arise from Isl1 deletion in murine pituitary progenitors. J Clin Invest. 2020 Aug 3;130(8):4501-4515
1	J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1	J:272505 Catela C, Correa E, Wen K, Aburas J, Croci L, Consalez GG, Kratsios P, An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development. Neural Dev. 2019 Jan 18;14(1):2
1	J:95393 Cepeda-Nieto AC, Pfaff SL, Varela-Echavarria A, Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons. Mol Cell Neurosci. 2005 Jan;28(1):30-41
1*	J:90448 Cha KB, Douglas KR, Potok MA, Liang H, Jones SN, Camper SA, WNT5A signaling affects pituitary gland shape. Mech Dev. 2004 Feb;121(2):183-94
1	J:284139 Chaimowicz C, Ruffault PL, Cheret C, Woehler A, Zampieri N, Fortin G, Garratt AN, Birchmeier C, Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. Development. 2019 Sep 6;146(17):dev174045
1	J:304721 Chang SH, Su YC, Chang M, Chen JA, MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs. Elife. 2021 Mar 31;10:e63768
1	J:238975 Clovis YM, Seo SY, Kwon JS, Rhee JC, Yeo S, Lee JW, Lee S, Lee SK, Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes. Cell Rep. 2016 Aug 09;16(6):1642-52
1	J:139297 Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM, Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell. 2008 Jul 25;134(2):304-16
1	J:235514 Davis SW, Mortensen AH, Keisler JL, Zacharias AL, Gage PJ, Yamamura K, Camper SA, beta-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis. BMC Dev Biol. 2016;16(1):16
1	J:299679 Debrulle S, Baudouin C, Hidalgo-Figueroa M, Pelosi B, Francius C, Rucchin V, Ronellenfitch K, Chow RL, Tissir F, Lee SK, Clotman F, Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cell Mol Life Sci. 2020 Oct;77(20):4117-4131
1	J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
1	J:262472 Edmond M, Hanley O, Philippidou P, Topoisomerase IIbeta Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0404-17.2017
1	J:158231 Francius C, Clotman F, Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience. 2010 Jan 13;165(1):116-29
1	J:231503 Gergics P, Brinkmeier ML, Camper SA, Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia. Mol Endocrinol. 2015 Apr;29(4):597-612
1*	J:229257 Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y, Yoshida Y, Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550
1	J:195620 Gumbel JH, Patterson EM, Owusu SA, Kabat BE, Jung DO, Simmons J, Hopkins T, Ellsworth BS, The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS One. 2012;7(12):e52156
1*	J:139734 Hafler BP, Choi MY, Shivdasani RA, Rowitch DH, Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30;1222:42-50
1	J:253351 Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS, Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
1*	J:143548 Himes AD, Raetzman LT, Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol. 2009 Jan 1;325(1):151-61
1	J:166771 Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, Stoeckli ET, Kiehn O, Arnold HH, The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development. 2010 Dec;137(24):4249-60
1	J:345795 Hsu HC, Hsu SP, Hsu FY, Chang M, Chen JA, LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons. iScience. 2024 Mar 15;27(3):109207
1	J:107594 Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL, Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 2005 Dec 22;48(6):949-64
1	J:112635 Ji SJ, Zhuang B, Falco C, Schneider A, Schuster-Gossler K, Gossler A, Sockanathan S, Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons. Dev Biol. 2006 Sep 1;297(1):249-61
1	J:186538 Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y, Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord. J Neurosci. 2012 Jul 25;32(30):10396-407
1	J:153666 Kawase-Koga Y, Otaegi G, Sun T, Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn. 2009 Nov;238(11):2800-12
1	J:266544 Kim J, Choi TI, Park S, Kim MH, Kim CH, Lee S, Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains. Development. 2018 Sep 3;145(17):dev165340
1	J:195163 Lacombe J, Hanley O, Jung H, Philippidou P, Surmeli G, Grinstein J, Dasen JS, Genetic and functional modularity of Hox activities in the specification of limb-innervating motor neurons. PLoS Genet. 2013 Jan;9(1):e1003184
1	J:328860 Lee S, Lee B, Joshi K, Pfaff SL, Lee JW, Lee SK, A regulatory network to segregate the identity of neuronal subtypes. Dev Cell. 2008 Jun;14(6):877-89
1	J:96957 Lee SK, Jurata LW, Nowak R, Lettieri K, Kenny DA, Pfaff SL, Gill GN, The LIM domain-only protein LMO4 is required for neural tube closure. Mol Cell Neurosci. 2005 Feb;28(2):205-14
1	J:213871 Li X, Liu Z, Qiu M, Yang Z, Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord. Development. 2014 Jul;141(14):2875-84
1*	J:75868 Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH, Common developmental requirement for olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 5;109(1):75-86
1	J:153192 Morikawa Y, Hisaoka T, Senba E, Characterization of Foxp2-expressing cells in the developing spinal cord. Neuroscience. 2009 Sep 15;162(4):1150-62
1	J:156251 Morikawa Y, Komori T, Hisaoka T, Senba E, Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis. Dev Neurosci. 2009;31(6):511-22
1	J:277700 Nam H, Jeon S, An H, Yoo J, Lee HJ, Lee SK, Lee S, Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification. Elife. 2019 Jul 15;8:e46683
1	J:245216 Osmundsen AM, Keisler JL, Taketo MM, Davis SW, Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation. Endocrinology. 2017 Oct 01;158(10):3339-3353
1	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
1	J:79850 Raetzman LT, Ward R, Camper SA, Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development. 2002 Sep;129(18):4229-39
1	J:274433 Roy A, Francius C, Rousso DL, Seuntjens E, Debruyn J, Luxenhofer G, Huber AB, Huylebroeck D, Novitch BG, Clotman F, Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012 Sep;139(17):3109-19
1	J:317827 Sawai A, Pfennig S, Bulajic M, Miller A, Khodadadi-Jamayran A, Mazzoni EO, Dasen JS, PRC1 sustains the integrity of neural fate in the absence of PRC2 function. Elife. 2022 Jan 7;11:e72769
1	J:73774 Suh H, Gage PJ, Drouin J, Camper SA, Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development. 2002 Jan;129(2):329-37
1	J:293140 Toch M, Harris A, Schakman O, Kondratskaya E, Boulland JL, Dauguet N, Debrulle S, Baudouin C, Hidalgo-Figueroa M, Gow A, Glover JC, Tissir F, Clotman F, Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits. Sci Rep. 2020 Jan 22;10(1):996
1	J:306250 Wang W, Cho H, Kim D, Park Y, Moon JH, Lim SJ, Yoon SM, McCane M, Aicher SA, Kim S, Emery B, Lee JW, Lee S, Park Y, Lee SK, PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway. Cell Rep. 2020 Sep 15;32(11):108147
1	J:321501 Wang W, Cho H, Lee JW, Lee SK, The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development. Nat Commun. 2022 Feb 17;13(1):958
1	J:290593 Yen YP, Hsieh WF, Tsai YY, Lu YL, Liau ES, Hsu HC, Chen YC, Liu TC, Chang M, Li J, Lin SP, Hung JH, Chen JA, Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity. Elife. 2018 Oct 12;7:e38080
1	J:182725 Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ, Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell. 2012 Mar 13;22(3):585-96
1*	J:119270 Zhao Y, Morales DC, Hermesz E, Lee WK, Pfaff SL, Westphal H, Reduced expression of the LIM-homeobox gene Lhx3 impairs growth and differentiation of Rathke's pouch and increases cell apoptosis during mouse pituitary development. Mech Dev. 2006 Aug;123(8):605-13
1	J:217063 Zou M, Luo H, Xiang M, Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn. 2015 Jan;244(1):86-97